Kristen Aiemjoy, MSc PhD(c) Doctoral Candidate, Department of Epidemiology & Biostatistics, NRSA Fellow, National Institute of Child Health and Development
Title: Defining Diarrhea: Validating and improving symptoms-based measures of pediatric diarrhea
Summary: Diarrhea is a major contributor to global child morbidity and mortality with an estimated 2 billion cases and 525,000 deaths every year. Most epidemiologic studies, surveillance programs and trials measure diarrhea using caregiver-reported symptoms. For her dissertation work, Kristen conducted a large validation study of caregiver-reported stool consistency within two clinical trials in the Amhara region of Ethiopia. She used the resulting misclassification estimates to adjust for measurement error and also explored variation in viral species richness across stool consistency types.
Kathryn J. Ray, MA
PhD Candidate, Department of Epidemiology & Biostatistics, University of California, San Francisco
Title: Mass antibiotic interventions— How can we assess the impact on gut microbiome at the community level?
Summary: Antibiotics decrease diversity in the gut microbiota of an individual (α-diversity). Community-based interventions, such as mass distributions of antibiotics, could impact the diversity within a community (γ-diversity). We estimated the γ-diversity of a community using laboratory-pooled specimens. After validation, we tested the effect of mass antibiotic treatment on gut diversity in MORDOR, a recent cluster randomized trial of mass azithromycin.