UCSF Medical School embraces the principles of clinical and translational medicine and continuously strives to improve medical education to nurture future medical leaders. In support of this critical mission, the Dept. of Epidemiology & Biostatistics (DEB) leads instruction on "Epidemiology and Evidence-Based Medicine" (EEBM) to the UCSF medical students, and co-sponsors one of the Essential Core Courses, entitled "Mechanisms, Methods, & Malignancies" (M3) that occurs for eight weeks during the second year of medical school. In the Essential Core, medical students learn the fundamentals of study design, confounding, bias, and common biostatistical analysis approaches to allow them to critically read and evaluate the medical literature. During the M3 course, EEBM is interwoven with material on oncology, molecular biology, genetics, and social and behavioral science and framed as a foundational topic that links together the bench to bedside, bedside to community principles of personalized medicine and translational science. In the Essential and Clinical Cores, the DEB also teaches how scientific and medical evidence are used to guide public health policy and clinical practice, using examples from screening and cancer prevention. The EEBM curriculum directly supports one of the key competencies areas (Practice-Based Learning) required for medical school matriculation.