Biostatistical Methods for Clinical Research IV (BIOSTAT 210)

Fall 2022 (2 units)

This is a fourth course in statistics, covering advanced methods for building and evaluating regression models. The emphasis is on methods which cut across common families of regression models in biostatistics: cubic splines, missing data, causal inference, and model diagnostics and model comparisions.  The statistics package Stata will be used throughout the course.

Online Syllabus


The specific objectives of this course are to:

  • understand cubic splines and their applications.
  • understand the missing at random assumption and critique its application.
  • implement multiple imputation for missing data.
  • apply regression to formulate causal estimands.
  • develop and critique prediction models.


Designing Clinical Research (EPI 202), Biostatistical Methods I (Biostat 200), Biostatistical Methods II (BIOSTAT 208) and III (BIOSTAT 209). Exceptions may be made with the consent of the course director, space permitting.


Course Director: David Glidden, PhD

Professor of Epidemiology & Biostatistics
email: [email protected]


Large Group Discussion

Brief formal review of lecture followed by question and answer discussion.
Time: Tuesdays, 10:30 AM to 12:00 PM, beginning September 13

Computer Laboratory
Course faculty are available to address questions on course assignments
Time: Tuesdays, 3:15 PM to 4:15 PM, September 27, October 11, 25, November 8

All course materials and handouts will be posted on the course's online syllabus.


Regression Methods in Biostatistics by Vittinghoff et al. Springer Publisher. 2nd Edition. 2012. An electronic copy of the book is available from the UCSF library:  (UCSF sign-in required)

The statistical software package Stata (Stata Corporation, College Station, TX) is used throughout the TICR Program and is required for this course; version 16 or higher is acceptable. A six-month student license for Stata/BE is the least expensive option that will be suitable to complete all course assignments. For students intending to enroll in courses over 1-2 years, an annual or perpetual license are better long-term options. If your research requires working with more variables, you also may wish to consider Stata/SE. We recommend that you have a personal copy of Stata and bring it on a laptop for all course sessions. Stata may be purchased at a discount for UCSF faculty/staff and official UCSF Students. You must use your email address to receive the discount. If you do not purchase your own copy of Stata, UCSF faculty/staff/students may request access to Stata through the UCSF Research Analysis Environment.

Books may be purchased either through the publisher or a variety of commercial venues (e.g.,


Grades will be based on 6 homework assignments.

Students not in full-year TICR Programs who satisfactorily pass all course requirements will, upon request, receive a Certificate of Course Completion.

UCSF Graduate Division Policy on Disabilities

To Enroll

ATCR and MAS students use the Student Portal

Students taking individual courses:

Course Fees
How to pay (please read before applying)
Fall Course Schedule

Apply by September 12, 2022 for Fall quarter

Only one application needs to be completed for all courses desired during the quarter.