Titled "Lifecourse reproductive and social-environmental determinants of Alzheimer's disease (AD) risk," the funded work builds on Dr. Torres's ongoing National Institute on Aging-funded community-based cohort study of midlife women living in California's Salinas Valley. This cohort leverages over a quarter-century of information on women's health and social and environmental exposures to begin to understand the impacts of these factors on cognitive and brain aging. This new funding will allow the research team to continue tracking their participants across the menopausal transition so that they can examine the role of reproductive aging in shaping dementia risk factors, including in the context of social and environmental exposures. The team will also begin to evaluate fluid AD biomarkers. This study is extremely unique in facilitating work on the relationship between pesticides and both reproductive and cognitive aging using rigorous longitudinal and prospective measures of exposures and outcomes.
