Breast cancer risk prediction based on polygenic risk scores (PRS) has improved since the first genome-wide association study published in 2007. However, the discovery of risk-associated variants and the estimation of effect sizes, which are relevant for building PRS, has been primarily based on data from populations of European ancestry. The seminar will describe progress in breast cancer-associated variant discovery and PRS-based risk prediction in Hispanic/Latinx and Latin American individuals in the United States and a collaborative effort to shorten the data gap.
Speaker: Laura Fejerman, PhD, Professor, Department of Public Health, UC Davis
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