PhD Dissertation
Yusuph Mavura, MS, PhD Candidate, Epidemiology and Translational Science
This dissertation uses clinical data based on longitudinal, real-world electronic health records to examine (1) the prediction accuracy of blood pressure polygenic scores by sex, age, and ancestry groups, (2) associations between these polygenic scores and target organ damage outcomes, such as incident ischemic stroke, and (3) reduction in blood pressure from antihypertension medications by ancestry and drug classes. Using longitudinal, real-world data, this dissertation offers unique insights into blood pressure genetics and antihypertension treatment effects across population groups.
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