Double Negative Control Inference in Test-Negative Design Studies of Vaccine Effectiveness

November 30, 2022
3:00 - 4:00pm
via Zoom

The test-negative design (TND) has become a standard approach to evaluate vaccine effectiveness, however, it remains subject to various potential biases. In this talk, we present a novel approach to identify and estimate vaccine effectiveness by leveraging a pair of negative control exposure and outcome variables to account for hidden bias in TND studies. We illustrate our proposed method with extensive simulation and an application to COVID-19 vaccine effectiveness using data from the University of Michigan Health System.

Speaker: Xu Shi, PhD, Assistant Professor of Biostatistics, University of Michigan


To obtain a Zoom link, please email [email protected].

Event Type: 
Biostatistics and Bioinformatics Seminar