Chuck Huber will introduce the concepts and jargon of multilevel mod
Chuck Huber will introduce different mechanisms that lead to missing
Lecture by Jack Rivers-Auty, Post-doctoral @ University of Manchester.
Kathryn J. Ray, MA
PhD Candidate, Department of Epidemiology & Biostatistics, University of California, San Francisco
Title: Mass antibiotic interventions— How can we assess the impact on gut microbiome at the community level?
Summary: Antibiotics decrease diversity in the gut microbiota of an individual (α-diversity). Community-based interventions, such as mass distributions of antibiotics, could impact the diversity within a community (γ-diversity). We estimated the γ-diversity of a community using laboratory-pooled specimens. After validation, we tested the effect of mass antibiotic treatment on gut diversity in MORDOR, a recent cluster randomized trial of mass azithromycin.
Thomas Travison, PhD, Director, Biostatistics and Clinical Trials, Institute for Aging Research, Assistant Professor of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center.
Title: Dynamic Data Analysis for Reproducible Research: Tools for Study Monitoring Presentation
Summary: The striking lack of replicability of major research findings in translational research has underscored the need for better design, documentation, and review of quantitative analyses. With modern software tools, the production of reproducible research -defined as the integrated combination of analytic methods, tools and replicable results -has become plausible in everyday practice.In this presentation we will describe our experience developing a customizable system of reusable and shareable modules for study monitoring, exploratory data analysis, reporting, and dissemination in aging. We focus specifically on platform-independent, web-based monitoring and analytic tools that permit collaboration and version-control among members of a translational research team, including quantitative scientists, clinical and nonclinical investigators, and skilled project staff. Use of these tools will be illustrated in an efficacy study of anutritional intervention, a cluster randomized trial of a mind-body intervention in supportive housing, and a patient-level diagnostic instrument using bioimages from MRI.