How do phenotypic changes confer advantage in natural selection? In this talk, I will describe our work understanding this question for the germinal center, which is where antibody-making B cells compete to bind pathogen-associated molecules called antigen. Using transgenic mice and deep mutational scanning, we have replicate evolutionary histories and a clear view of the affinity landscape of these B cells.
Speaker: Erick Matsen, PhD, Professor, Public Health Sciences Division, Fred Hutch Cancer Center
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